Liste des publications scientifiques du CHU de Clermont-Ferrand

Cette liste prend en compte l'ensemble des publications scientifiques du CHU référencées sur PubMed de 1973 au 31.12.2020

Auteurs : Raskovalova, T; Deegan, PB; Mistry, PK; Labarère, J; Berger, MG ; et al.

Revue : Haematologica - ISSN : 1592-8721 - NLMID : 0417435
Date de Publication : Janvier 2020


Résumé : Chitotriosidase activity and CCL18 concentration are interchangeably used for monitoring Gaucher disease (GD) activity, together with clinical assessment. However, comparative studies of these two biomarkers are scarce and of limited sample size. The aim of this systematic review with meta-analysis of individual participant data (IPD) was to compare the accuracy of chitotriosidase activity and CCL18 concentration for assessing type I GD severity. We identified cross-sectional and prospective cohort studies by searching Medline, EMBASE, and CENTRAL from 1995 to June 2017, and by contacting research groups. The primary outcome was a composite of liver volume >1.25 multiple of normal (MN), spleen volume >5 MN, hemoglobin concentration <11 g/dL, and platelet count <100x109/L. Overall, IPD included 1109 observations from 334 patients enrolled in nine primary studies, after excluding 111 patients with undocumented values and 18 patients with deficient chitotriosidase activity. IPD were unavailable for 14 eligible primary studies. The primary outcome was associated with a 5.3-fold (95% confidence interval [CI], 4.2 to 6.6) and 3.0-fold (95% CI, 2.6 to 3.6) increase of the geometric mean for chitotriosidase activity and CCL18 concentration, respectively. The corresponding areas under the receiver operating characteristics curves were 0.82 and 0.84 (summary difference, 0.02, 95% CI, -0.02 to 0.05). The addition of chitotriosidase activity did not improve the accuracy of CCL18 concentration. Estimates remained robust in the sensitivity analysis and consistent across subgroups. Neither chitotriosidase activity nor CCL18 concentration varied significantly according to a recent history of bone events among 97 patients. In conclusion, CCL18 concentration is as accurate as chitotriosidase activity in assessing hematological and visceral parameters of GD severity and can be measured in all GD patients. This meta-analysis supports the use of CCL18 rather than chitotriosidase activity for monitoring GD activity in routine practice.

Mots clés auteurs : /Biomarkers/Gaucher disease/Granulocytes, Monocytes, Macrophages

Auteurs : Grosse, J; Allado, E; Roux, C; Chary-Valckenaere, I; Loeuille, D ; et al.

Revue : Rheumatology international - ISSN : 1437-160X - NLMID : 8206885
Date de Publication : Avril 2020
Vol. : 40 Numéro 4 Pages : 615-624


Résumé : The objective of this study is to assess the prevalence, localization, and severity of bone erosions on radiography (RX) and ultrasonography (US) according to ACPA status in patients with rheumatoid arthritis (RA). 78 patients with ACPA-positive (ACPA+) RA and 30 patients with ACPA-negative (ACPA-) RA fulfilling the ACR 1987 and/or ACR/EULAR 2010 criteria were consecutively included. On RX, a modified Sharp erosion score (SHSe) was evaluated by two blinded readers and one adjudicator for discordant cases (number of eroded joints???three). On US, erosions were scored on six bilateral joints (MCP2, 3, 5; MTP2, 3, 5) with a four-point scale to calculate the total US score for erosions (USSe). The mean total SHSe and USSe were 3.7 and 4.4 times higher in the ACPA+?group than in the ACPA- group, respectively (P?<?0.001). On both RX and US, the most discriminating joint between the two groups was MTP5, especially in cases with bilateral erosion. Based on multivariate analyses, ACPA?+?status was associated with erosive RA on RX according to the EULAR 2013 definition criteria [OR 4.4 (95% CI 1.2-16.4)], and on US according to the following two definitions: the presence of at least two eroded joint facets [OR 3.7 (95% CI 1.4-9.9)] or at least one grade 2 joint facet erosion [OR 9.0 (95% CI 2.8-28.4)]. Compared to ACPA- RA, ACPA?+?RA is associated independently with more severe erosive disease on RX and US. Both US and RX bilateral erosions in MTP5 joints are highly discriminant for ACPA?+?RA patients (97.8% in US and 100% in RX).

Mesh : Adult|Aged|Anti-Citrullinated Protein Antibodies/immunology|Arthritis, Rheumatoid/classification/diagnostic imaging/pathology|Disease Progression|Enzyme-Linked Immunosorbent Assay|Female|Foot Joints/diagnostic imaging/pathology|Hand Joints/diagnostic imaging/pathology|Humans|Male|Middle Aged|Radiography|Retrospective Studies|Ultrasonography

Mots clés auteurs : /ACPA/Bone erosion/Erosive disease/Radiography/Rheumatoid arthritis/Ultrasonography

Auteurs : Takigawa, M; Vlachos, K; Martin, CA; Jaïs, P; Derval, N ; et al.

Revue : Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology - ISSN : 1532-2092 - NLMID : 100883649
Date de Publication : Août 2020
Vol. : 22 Numéro 8 Pages : 1252-1260


Résumé : We hypothesized that an epicardial approach using ethanol infusion in the vein of Marshall (EIVOM) Mai improve the result of ablation for perimitral flutter (PMF).We studied 103 consecutive patients with PMF undergoing high-resolution mapping. The first 71 were treated with radiofrequency (RF) ablation alone (RF-group), and the next 32 underwent EIVOM followed by RF on the endocardial and epicardial mitral isthmus (EIVOM/RF-group). Contact force was not measured during ablation. Acute and 1-year outcomes were compared. Flutter termination rates were similar between the RF-group (63/71, 88.7%) and EIVOM/RF-group (31/32, 96.8%, P?=?0.27). Atrial tachycardia (AT) terminated with EIVOM alone in 22/32 (68.6%) in the EIVOM/RF-group. Bidirectional block of mitral isthmus was always achieved in the EIVOM/RF-group, but significantly less frequently achieved in the RF-group (62/71, 87.3%; P?=?0.05). Median RF duration for AT termination/conversion was shorter [0 (0-6) s in the EIVOM/RF-group than 312 (55-610) s in the RF-group, P?<?0.0001], as well as for mitral isthmus block in the EIVOM/RF-group [246 (0-663) s] than in the RF-group [900 (525-1310) s, P?<?0.0001]. Pericardial effusion was observed in 1/32 (3.2%) in EIVOM/RF-group and 5/71 (7.0%) in RF-group (P?=?0.66); two in RF-group required drainage and one of them developed subsequent ischaemic stroke. One-year follow-up demonstrated fewer recurrences in the EIVOM/RF-group [6/32 (18.8%)] than in the RF-group [29/71 (40.8%), P?=?0.04]. By multivariate analysis, only EIVOM was significantly associated with less AT recurrence (hazard ratio?=?0.35, P?=?0.018).Ethanol infusion in the vein of Marshall Mai reduce RF duration required for PMF termination as well as for mitral isthmus block without severe complications, and the mid-term outcome Mai be improved by this approach.

Mots clés auteurs : /Atrial tachycardia/Catheter ablation/Epicardial conduction/Ethanol/High-resolution mapping/Vein of Marshall

Auteurs : Saidi, O; Rochette, E; Bovet, M; Merlin, E; Duché, P ;

Revue : Pediatric obesity - ISSN : 2047-6310 - NLMID : 101572033
Date de Publication : Juin 2020
Vol. : 15 Numéro 6 Pages : e12613


Résumé : Although adolescence and obesity are related to impaired sleep duration and quality, exercise was admitted as a nonpharmacological treatment for sleep and better control of energy balance.To investigate the acute effects of intense exercise on sleep and subsequent dietary intake.Sixteen adolescent girls with obesity (age 13.7?±?1.1?years, weight 82.7?±?10.2 kg, body mass index (BMI) 30.5?±?3.4 kg/m2 , fat mass (FM) 39.2?±?3.1%, Pittsburgh Sleep Quality Index (PSQI) 8.6?±?2.8, paediatric daytime sleepiness scale (PDSS) 19.6?±?5.9) took part in two experimental sessions in a random order: Control (CTL) and Exercise (EX). The two sessions were identical except for a continuous ergocycle exercise bout lasting 40?minutes and performed at 70% VO2max at the end of the morning of EX. Energy expenditure and sleep were measured by accelerometry and next-morning dietary intake in an ad libitum meal.Higher sleep duration (P?<?0.03) and quality (decreased WASO: P?<?0.02; increased SE%: P?<?0.02) were observed in EX compared with CTL. This was associated with a nonsignificant decrease in caloric intake (-78?kcal) and a significant decrease in food energy density (P?<?0.04), fat, and sugar consumption (respectively, P?<?0.02 and P?<?0.05) the following morning.Acute exercise efficaciously increased sleep duration and quality, resulting in a decrease in subsequent energy-dense food consumption in adolescent girls with obesity.

Mesh : Adolescent|Body Mass Index|Child|Energy Intake|Energy Metabolism|Exercise|Female|Humans|Obesity/physiopathology/psychology|Sleep

Mots clés auteurs : /accelerometry/dietary behaviour/girls with obesity/physical activity/sleep

Auteurs : Dupuit, M; Boscaro, A; Bonnet, A; Rance, M; Boisseau, N ; et al.

Revue : Scandinavian journal of medicine & science in sports - ISSN : 1600-0838 - NLMID : 9111504
Date de Publication : Décembre 2020
Vol. : 30 Numéro 12 Pages : 2352-2363


Résumé : This pilot study compared the effects of acute high-intensity intermittent exercise (HIIE) and moderate-intensity continuous exercise (MICE) on post-exercise VO2 , fat utilization, and 24-hours energy balance to understand the mechanism of higher fat mass reduction observed after high-intensity interval training in post-menopausal women with overweight/obesity. 12 fasted women (59.5 ± 5.8 years; BMI: 28.9 ± 3.9 kg·m-2 ) completed three isoenergetic cycling exercise sessions in a counterbalanced, randomized order: (a) MICE [35 minutes at 60%-65% of peak heart rate, HRmax ], (b) HIIE 1 [60 × (8-s cycling-12-s recovery) at 80%-90% of HRmax ], and (c) HIIE 2 [10 × 1min at 80%-90% of HRmax  - 1-min recovery]. Then, VO2 and fat utilization measured at rest and during the 2 hours post-exercise, enjoyment, perceived exertion, and appetite recorded during the session and energy intake (EI) and energy expenditure (EE) assessed over the next 24 hours were compared for the three modalities. Overall, fat utilization increased after exercise. No modality effect or time-modality interaction was observed concerning VO2 and fat oxidation rate during the 2 hours post-exercise. The two exercise modalities did not induce specific EI and EE adaptations, but perceived appetite scores at 1 hour post-exercise were lower after HIIE 1 and HIIE 2 than MICE. Perceived exertion was higher during HIIE 1 and HIIE 2 than MICE, but enjoyment did not differ among modalities. The acute HIIE responses did not allow explaining the greater fat mass loss observed after regular high-intensity interval training in post-menopausal women with overweight/obesity. More studies are needed to understand the mechanisms involved in such adaptations.

Mesh : Appetite|Blood Glucose/metabolism|Body Fat Distribution|Energy Metabolism|Exercise/physiology|Female|Heart Rate|High-Intensity Interval Training|Humans|Lipid Metabolism|Middle Aged|Obesity/metabolism|Overweight/metabolism|Oxygen Consumption|Perception/physiology|Physical Exertion/physiology|Pilot Projects|Pleasure|Postmenopause/physiology|Pulmonary Gas Exchange

Mots clés auteurs : /appetite/energy balance/enjoyment/exercise modalities/exertion/lipid utilization/post-exercise oxygen consumption/post-menopausal women

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