Liste des publications scientifiques du CHU de Clermont-Ferrand

Cette liste prend en compte l'ensemble des publications scientifiques du CHU référencées sur PubMed de 1973 au 31.12.2020

Auteurs : Hoertel, N; Rotenberg, L; Blanco, C; Limosin, F; , ; et al.

Revue : Social psychiatry and psychiatric epidemiology - ISSN : 1433-9285 - NLMID : 8804358
Date de Publication : Mai 2020

Résumé : Numerous factors are known to influence quality of life of adults with schizophrenia. However, little is known regarding the potential predictors of quality of life in the increasing population of older adults with schizophrenia. The main objective of the present study was to propose a comprehensive model of quality of life in this specific population.Data were derived from the Cohort of individuals with Schizophrenia Aged 55 years or more (CSA) study, a large (N?=?353) multicenter sample of older adults with schizophrenia or schizoaffective disorder recruited from French community mental-health teams. We used structural equation modeling to simultaneously examine the effects of six broad groups of clinical factors previously identified as potential predictors of quality of life in this population, including (1) severity of general psychopathology, (2) severity of depression, (3) severity of cognitive impairment, (4) psychotropic medications, (5) general medical conditions and (6) sociodemographic characteristics.General psychopathology symptoms, and in particular negative and depressive symptoms, cognitive impairment, reduced overall functioning and low education were significantly and independently associated with diminished quality of life (all p?<?0.05). Greater number of medical conditions and greater number of antipsychotics were also independently and negatively associated with quality of life, although these associations did not reach statistical significance in sensitivity analyses, possibly due to limited statistical power.Several domains are implicated in quality of life among older adults with schizophrenia. Interventions targeting these factors Mai help improve importantly quality of life of this vulnerable population.

Mots clés auteurs : /Antipsychotics/Cognition/Comprehensive model/Depression/Elderly/Late-life/Older/Quality of life/Schizophrenia/Structural equation modeling/Symptoms

Auteurs : Bennett, JH; Beeley, JA; Anderson, P; Vandamme, K; Manzanares, MC ; et al.

Revue : European journal of dental education : official journal of the Association for Dental Education in Europe - ISSN : 1600-0579 - NLMID : 9712132
Date de Publication : Août 2020
Vol. : 24 Numéro 3 Pages : 433-441

Résumé : The biomedical sciences (BMS) are a central part of the dental curriculum that underpins teaching and clinical practice in all areas of dentistry. Although some specialist groups have proposed curricula in their particular topic areas, there is currently no overarching view of what should be included in a BMS curriculum for undergraduate dental programmes. To address this, the Association for Dental Education in Europe (ADEE) convened a Special Interest Group (SIG) with representatives from across Europe to develop a consensus BMS curriculum for dental programmes.This paper summarises the outcome of the deliberations of this SIG and details a consensus view from the SIG of what a BMS curriculum should include.Given the broad nature of BMS applied to dentistry, this curriculum framework is advisory and seeks to provide programme planners with an indicative list of topics which can be mapped to specific learning objectives within their own curricula. As dentistry becomes increasingly specialised, these will change, or some elements of the undergraduate curriculum Mai move to the post-graduate setting. So, this document should be seen as a beginning and it will need regular review as BMS curricula in dentistry evolve.

Mesh : Consensus|Curriculum|Dentistry|Education, Dental|Europe

Mots clés auteurs : /biomedical science/curriculum/dentistry/undergraduate

Auteurs : Serratrice, C; Stirnemann, J; Berrahal, A; Yousfi, K; Berger, MG ; et al.

Revue : Journal of clinical medicine - ISSN : 2077-0383 - NLMID : 101606588
Date de Publication : Juillet 2020
Vol. : 9 Numéro 8

Résumé : Patients with type 1 Gaucher disease (GD1) present thrombocytopenia, anemia, organomegaly, and bone complications. Most experts consider that the less aggressive forms do not require specific treatment. However, little is known about the disease course of these forms. The objective of this cross-sectional retrospective study was to compare the clinical, radiological, and laboratory characteristics of patients with less severe GD1 at diagnosis and at the last evaluation to identify features that might lead to potential complications. Non-splenectomized and never-treated patients (19 women and 17 men) were identified in the French Gaucher Disease Registry (FGDR). Their median age was 36.6 years (2.4-75.1), and their median follow-up was 7.8 years (0.4-32.4). Moreover, 38.7% were heterozygous for the GBA1 N370S variant, and 22.6% for the GBA1 L444P variant. From diagnosis to the last evaluation, GD1 did not worsen in 75% of these patients. Some parameters improved (fatigue and hemoglobin concentration), whereas platelet count and chitotriosidase level remained stable. In one patient (2.7%), Lewy body dementia was diagnosed at 46 years of age. Bone lesion onset was late and usually a single event in most patients. This analysis highlights the genotypic heterogeneity of this subgroup, in which disease could remain stable and even improve spontaneously. It also draws attention to the possible risk of Lewy body disease and late onset of bone complications, even if isolated, to be confirmed in larger series and with longer follow-up.

Mots clés auteurs : /Gaucher disease/disease course/enzyme replacement therapy/lysosomal storage disorder/prognosis/risk factors

Auteurs : Lahaye, C; Sanchez, M; Rouet, A; Raynaud-Simon, A; Lilamand, M ; et al.

Revue : Age and ageing - ISSN : 1468-2834 - NLMID : 375655
Date de Publication : Avril 2020
Vol. : 49 Numéro 3 Pages : 487-489

Résumé : A 70-year-old patient was admitted with rapidly progressive cognitive decline associated with limitations in activities of daily living, weight loss and cerebellar ataxia. The diagnosis of giant cell arteritis (GCA) with vascular involvement was made, based on the presence of a metabolically active vasculitis of the brachiocephalic trunk on 18FDG-PET imaging. Temporal artery biopsy also revealed pan-arteritis. A progressive regression of cognitive disorders occurred under corticosteroid treatment and immunosuppressive therapy. Previously published case reports concerning this atypical presentation of GCA are scarce. They suggest that numerous cognitive symptoms, such as impairment of short-term memory, disorientation, delirium, impaired attention or visual hallucinations might be related to GCA. Thus, this diagnosis should be considered as a curable cause of unexplained cognitive impairment associated with weight loss and systemic inflammation.

Mots clés auteurs : /cerebral vasculitis/dementia/giant cell arteritis/older people/reversible cognitive impairment

Auteurs : Hayes, A; Nguyen, D; Andersson, M; Harvala, H; Simmonds, P ; et al.

Revue : Journal of medical virology - ISSN : 1096-9071 - NLMID : 7705876
Date de Publication : Août 2020
Vol. : 92 Numéro 8 Pages : 1065-1074

Résumé : Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate sample types and high assay sensitivity as viral loads in cerebrospinal fluid samples from meningitis and sepsis clinical presentation can be extremely low. This study evaluated the sensitivity and specificity of currently used commercial and in-house diagnostic and typing assays. Accurately quantified RNA transcript controls were distributed to 27 diagnostic and 12 reference laboratories in 17 European countries for blinded testing. Transcripts represented the four human EV species (EV-A71, echovirus 30, coxsackie A virus 21, and EV-D68), HPeV3, and specificity controls. Reported results from 48 in-house and 15 commercial assays showed 98% detection frequencies of high copy (1000 RNA copies/5?µL) transcripts. In-house assays showed significantly greater detection frequencies of the low copy (10 copies/5?µL) EV and HPeV transcripts (81% and 86%, respectively) compared with commercial assays (56%, 50%; P?=?7?×?10-5 ). EV-specific PCRs showed low cross-reactivity with human rhinovirus C (3 of 42 tests) and infrequent positivity in the negative control (2 of 63 tests). Most or all high copy EV and HPeV controls were successfully typed (88%, 100%) by reference laboratories, but showed reduced effectiveness for low copy controls (41%, 67%). Stabilized RNA transcripts provide an effective, logistically simple and inexpensive reagent for evaluation of diagnostic assay performance. The study provides reassurance of the performance of the many in-house assay formats used across Europe. However, it identified often substantially reduced sensitivities of commercial assays often used as point-of-care tests.

Mots clés auteurs : /PCR/RNA transcripts/enterovirus/enterovirus A71/parechovirus