Liste des publications scientifiques du CHU de Clermont-Ferrand

Cette liste prend en compte l'ensemble des publications scientifiques du CHU référencées sur PubMed de 1973 au 31.12.2020

Auteurs : Couderc, M; Bart, G; Coiffier, G; Guggenbuhl, P; , ; et al.

Revue : Joint bone spine - ISSN : 1778-7254 - NLMID : 100938016
Date de Publication : Décembre 2020
Vol. : 87 Numéro 6 Pages : 538-547

Résumé : Septic arthritis (SA) in an adult native joint is a rare condition but a diagnostic emergency due to the morbidity and mortality and the functional risk related to structural damage. Current management varies and the recommendations available are dated. The French Rheumatology Society (SFR) Bone and Joint Infection Working Group, together with the French Language Infectious Diseases Society (SPILF) and the French Orthopaedic and Trauma Surgery Society (SOFCOT) have worked according to the HAS methodology to devise clinical practice recommendations to diagnose and treat SA in an adult native joint. One new focus is on the importance of microbiological documentation (blood cultures and joint aspiration) before starting antibiotic treatment, looking for differential diagnoses (microcrystal detection), the relevance of a joint ultrasound to guide aspiration, and the indication to perform a reference X-ray. A cardiac ultrasound is indicated only in cases of SA involving Staphylococcus aureus, oral streptococci, Streptococcus gallolyticus or Enterococcus faecalis, or when infective endocarditis is clinically suspected. Regarding treatment, we stress the importance of medical and surgical collaboration. Antibiotic therapies (drugs and durations) are presented in the form of didactic tables according to the main bacteria in question (staphylococci, streptococci and gram-negative rods). Probabilistic antibiotic therapy should only be used for patients with serious symptoms. Lastly, non-drug treatments such as joint drainage and early physical therapy are the subject of specific recommendations.

Mots clés auteurs : /Bone and joint infection/Recommendation/Septic arthritis

Auteurs : Rushmore, RJ; Wilson-Braun, P; Papadimitriou, G; Kikinis, R; Makris, N ; et al.

Revue : Frontiers in neuroanatomy - ISSN : 1662-5129 - NLMID : 101477943
Date de Publication : Septembre 2020
Vol. : 14 Pages : 40

Résumé : The brainstem, a structure of vital importance in mammals, is currently becoming a principal focus in cognitive, affective, and clinical neuroscience. Midbrain, pontine and medullary structures serve as the conduit for signals between the forebrain and spinal cord, are the epicenter of cranial nerve-circuits and systems, and subserve such integrative functions as consciousness, emotional processing, pain, and motivation. In this study, we parcellated the nuclear masses and the principal fiber pathways that were visible in a high-resolution T2-weighted MRI dataset of 50-micron isotropic voxels of a postmortem human brainstem. Based on this analysis, we generated a detailed map of the human brainstem. To assess the validity of our maps, we compared our observations with histological maps of traditional human brainstem atlases. Given the unique capability of MRI-based morphometric analysis in generating and preserving the morphology of 3D objects from individual 2D sections, we reconstructed the motor, sensory and integrative neural systems of the brainstem and rendered them in 3D representations. We anticipate the utilization of these maps by the neuroimaging community for applications in basic neuroscience as well as in neurology, psychiatry, and neurosurgery, due to their versatile computational nature in 2D and 3D representations in a publicly available capacity.

Mots clés auteurs : /brainstem atlas/human brainstem anatomy/neuroimaging/ontology/terminologia anatomica/ultrahigh-resolution MRI

Auteurs : Cardoso, F; Paluch-Shimon, S; Senkus, E; Costa, A; Winer, EP ; et al.

Revue : Annals of oncology : official journal of the European Society for Medical Oncology - ISSN : 1569-8041 - NLMID : 9007735
Date de Publication : Septembre 2020
Mots clés auteurs : /ABC/ESO-ESMO/advanced/breast cancer/guidelines/metastatic

Auteurs : Villatte, G; van der Kruk, E; Bhuta, AI; Bull, AMJ; Reilly, P ; et al.

Revue : Journal of shoulder and elbow surgery - ISSN : 1532-6500 - NLMID : 9206499
Date de Publication : Octobre 2020
Vol. : 29 Numéro 10 Pages : 1967-1973

Résumé : The critical shoulder angle (CSA) has been shown to be correlated with shoulder disease states. The biomechanical hypothesis to explain this correlation is that the CSA changes the shear and compressive forces on the shoulder. The objective of this study is to test this hypothesis by use of a validated computational shoulder model. Specifically, this study assesses the impact on glenohumeral biomechanics of modifying the CSA.An inverse dynamics 3-dimensional musculoskeletal model of the shoulder was used to quantify muscle forces and glenohumeral joint forces. The CSA was changed by altering the attachment point of the middle deltoid into a normal CSA (33°), a reduced CSA of 28°, and an increased CSA of 38°. Subject-specific kinematics of slow and fast speed abduction in the scapular plane and slow and fast forward flexion measured by a 3-dimensional motion capture system were used to quantify joint reaction shear and compressive forces.Increasing the CSA results in increased superior-inferior forces (shearing forces; integrated over the range of motion; P < .05). Reducing CSA results in increased lateromedial (compressive) forces for both the maximum and integrated sum of the forces over the whole motion (P < .01).Changes in the CSA modify glenohumeral joint biomechanics with increasing CSA producing higher shear forces that could contribute to rotator cuff overuse, whereas reducing the CSA results in higher compressive forces that contribute to joint wear.

Mesh : Adult|Biomechanical Phenomena|Computer Simulation|Humans|Kinetics|Male|Models, Anatomic|Movement|Range of Motion, Articular|Shoulder Joint/physiopathology|Stress, Mechanical|Young Adult

Mots clés auteurs : /Critical shoulder angle (CSA)/computational shoulder model/glenohumeral joint/joint wear/rotator cuff

Auteurs : Sun, Y; Wang, A; Yu, S; Dutheil, F; Gao, Y ; et al.

Revue : BMC public health - ISSN : 1471-2458 - NLMID : 100968562
Date de Publication : Juin 2020
Vol. : 20 Numéro 1 Pages : 994

Résumé : Regular participation in moderate-to-vigorous physical activity (MVPA) is related to decreased risk of morbidity and mortality. Among working populations, lack of MVPA Mai also be a risk factor for absenteeism and presenteeism. Both traditional workplace-based and web-based interventions have been suggested as being effective in promoting participation MVPA, health-related outcomes, and work-related productivity. However, several challenges limit their application in real world contexts. A 'blended' intervention approach combining the two intervention strategies is proposed to overcome these limitations. The proposed intervention aims to utilize the blended approach to increase participation in MVPA, health-related outcomes, and work productivity among inactive workers.The study will comprise of a three-group cluster randomized controlled trial (cluster-RCT), comprising a three-month actual intervention and a nine-month behavioral follow-up period. The three groups will be: a web-based intervention group, a blended intervention group combining the web-based components with face-to-face workshops and posters, and a control group. Physically inactive office employees (N?=?495) from 33 companies (i.e., clusters) will be recruited and randomly assigned to the three groups by cluster randomization. The intervention mapping (IM) framework will be used for selecting and applying effective health behavioral theories and behavioral change techniques (BCTs) to the development, implementation and assessment of the intervention, which will be personally tailored. The primary outcome variable will be objectively-measured MVPA using an accelerometer. Secondary outcomes will consist of indices of health including adiposity, blood pressure, blood sugar, blood lipids, self-reported depression, anxiety, stress, health-related quality of life and work-related variables including absenteeism and presenteeism.The proposed study adopts a robust blended intervention approach that is expected to overcome challenges in applying workplace-based and web-based interventions separately and yield larger effects in promoting MVPA participation, health-related outcomes and work productivity. Improvements in work productivity outcomes will be of particular interest to employers. If more effective, the new blended intervention has the potential to be implemented on a larger scale to benefit workplace populations.The trial is prospectively registered at the PRS (Trial ID: NCT04391270; Date of First Posted: Mai 18, 2020).

Mesh : Adult|Behavior Therapy/methods|Exercise/psychology|Female|Health Promotion/methods|Hong Kong|Humans|Male|Middle Aged|Occupational Diseases/therapy|Occupational Health/statistics & numerical data|Risk Factors|Sedentary Behavior|Workplace/organization & administration/statistics & numerical data

Mots clés auteurs : /Blended intervention/Health promotion/Office employees/Physical activity/Web-based intervention/Work productivity